منابع مشابه
Rab GEFs and GAPs.
Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular tr...
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Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...
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Odorant perception is initiated when odorants activate unique combinations of odorant receptors (ORs) expressed in the cilia of olfactory sensory neurons in the nose (Buck and Axel 1991; Malnic et al. 1999). One of the greatest challenges in the olfactory science is to correlate ORs with their ligands (to deorphanize the ORs). The determination of OR– ligand pairs should reveal how the OR famil...
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NIH is preparing to announce plans for the pilot phase of their proposed Human Cancer Genome Project. This initiative seeks to provide a complete list of the mutations that give rise to cancer.
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n this article, I will review some current data on the incidence and mortality of prostate cancer and then discuss some possible new directions in prostate cancer, focusing on how discovery of genes may affect the way we approach this disease. None of us knows where the next great break is going to be in the treatment of localized, locally advanced, or advanced pros-tate cancer. If we did know,...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2009
ISSN: 1945-3477
DOI: 10.1038/scibx.2009.775